Ontology highlight
ABSTRACT:
SUBMITTER: Morokutti-Kurz M
PROVIDER: S-EPMC7888609 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Morokutti-Kurz Martina M Fröba Maria M Graf Philipp P Große Maximilian M Grassauer Andreas A Auth Janina J Schubert Ulrich U Prieschl-Grassauer Eva E
PloS one 20210217 2
In the absence of a vaccine and other effective prophylactic or therapeutic countermeasures the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) remains a significant public health threat. Attachment and entry of coronaviruses including SARS-CoV-2 is mainly mediated by the spike glycoprotein. Here, we show that iota-carrageenan can inhibit the cell entry of the SARS-CoV-2 spike pseudotyped lentivirus in a dose dependent manner. SARS-CoV-2 spike pseudotyped lentivirus particle ...[more]