Ontology highlight
ABSTRACT:
SUBMITTER: Slemmons KK
PROVIDER: S-EPMC7888706 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Slemmons Katherine K KK Deel Michael D MD Lin Yi-Tzu YT Oristian Kristianne M KM Kuprasertkul Nina N Genadry Katia C KC Chen Po-Han PH Chi Jen-Tsan Ashley JT Linardic Corinne M CM
Biology open 20210209 2
The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness properties of cancer cells in <i>in vitro</i> culture. However, a method to grow PAX3-FOXO1 fusion-positive rhabdomyosarcoma (FP-RMS), an aggressive soft tissue sarcoma of childhood, has to date not been reported, hampering efforts to identify the dysregulated signaling pathways that underlie FP-RMS stemness. Here, we first examine the expression of canonical stem cell markers in hum ...[more]