Ontology highlight
ABSTRACT:
SUBMITTER: Liu CL
PROVIDER: S-EPMC7890081 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Chien-Liang CL Cheng Shih-Ping SP Chen Ming-Jen MJ Lin Chi-Hsin CH Chen Shan-Na SN Kuo Yi-Hue YH Chang Yuan-Ching YC
Frontiers in endocrinology 20210204
Perturbed Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) homeostasis is involved in cancer progression and metastasis. Quinolinate phosphoribosyltransferase (QPRT) is the rate-limiting enzyme in the kynurenine pathway participating in NAD<sup>+</sup> generation. In this study, we demonstrated that QPRT expression was upregulated in invasive breast cancer and spontaneous mammary tumors from MMTV-PyVT transgenic mice. Knockdown of QPRT expression inhibited breast cancer cell migration and inv ...[more]