Addressing uncertainty in genome-scale metabolic model reconstruction and analysis.
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ABSTRACT:
SUBMITTER: Bernstein DB
PROVIDER: S-EPMC7890832 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Addressing uncertainty in genome-scale metabolic model reconstruction and analysis.
Bernstein David B DB Sulheim Snorre S Almaas Eivind E Segrè Daniel D
Genome biology 20210218 1
The reconstruction and analysis of genome-scale metabolic models constitutes a powerful systems biology approach, with applications ranging from basic understanding of genotype-phenotype mapping to solving biomedical and environmental problems. However, the biological insight obtained from these models is limited by multiple heterogeneous sources of uncertainty, which are often difficult to quantify. Here we review the major sources of uncertainty and survey existing approaches developed for rep ...[more]
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