Dataset Information

Polyostotic osteosarcoma associated with avian leukosis virus infection in a captive bare-faced curassow (Crax fasciolata).

ABSTRACT:

Background

Osteosarcoma is a malignant mesenchymal bone tumor. Although it is a common tumor in the appendicular skeleton of dogs and cats, it is rarely reported in birds. Retroviruses are usually associated with solid tumor development in different avian species.

Case presentation

This report aims to describe a case of osteosarcoma associated with the avian leukosis virus in a captive bare-faced curassow (Crax fasciolata). A captive adult female bare-faced curassow presented with lameness, hyporexia, and a non-ulcerative and firm tumor in the right femur. The bird was euthanized due to the poor prognosis. Histopathology revealed an infiltrative mesenchymal neoplasm consisting of spindle cells with moderate cell pleomorphism, organized in bundles and interspersed by marked deposition of the osteoid matrix, which was compatible with osteosarcoma affecting both femur and tibiotarsus, with renal metastasis. Immunohistochemistry of the primary and metastatic tumor demonstrated vimentin expression by neoplastic cells. Samples of the neoplasm, bone marrow, and spleen were processed for PCR, which enabled the demonstration of proviral avian leukosis virus (ALV) DNA.

Conclusions

To the best of our knowledge, this is the first report of an osteosarcoma in a bare-faced curassow with an unusual polyostotic manifestation and associated with ALV infection.

SUBMITTER: Oliveira JBS

PROVIDER: S-EPMC7890989 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Polyostotic osteosarcoma associated with avian leukosis virus infection in a captive bare-faced curassow (Crax fasciolata).

Oliveira Jefferson Bruno Soares JBS de Oliveira Ayisa Rodrigues AR Dos Santos Daniel Oliveira DO de Carvalho Thaynara Parente TP Moreira Larissa Giannini Alves LGA Tinoco Herlandes Penha HP Coelho Carlyle Mendes CM Coelho Hannah Luiza Gonsalves HLG de Paiva Zucherato Maria Clara MC Marín-Gómez Sandra Yuliet SY Costa Camila Siqueira CS Martins Nelson R S NRS Santos Renato Lima RL Santos Renato Lima RL

BMC veterinary research 20210218 1

<h4>Background</h4>Osteosarcoma is a malignant mesenchymal bone tumor. Although it is a common tumor in the appendicular skeleton of dogs and cats, it is rarely reported in birds. Retroviruses are usually associated with solid tumor development in different avian species.<h4>Case presentation</h4>This report aims to describe a case of osteosarcoma associated with the avian leukosis virus in a captive bare-faced curassow (Crax fasciolata). A captive adult female bare-faced curassow presented with ...[more]

PMID: 33602243

Similar Datasets

Project description:The J subgroup of avian leukosis virus (ALV-J) infects domestic chickens, jungle fowl, and turkeys. This virus enters the host cell through a receptor encoded by the tvj locus and identified as Na+/H+ exchanger 1. The resistance to avian leukosis virus subgroup J in a great majority of galliform species has been explained by deletions or substitutions of the critical tryptophan 38 in the first extracellular loop of Na+/H+ exchanger 1. Because there are concerns of transspecies virus transmission, we studied natural polymorphisms and susceptibility/resistance in wild galliforms and found the presence of tryptophan 38 in four species of New World quails. The embryo fibroblasts of New World quails are susceptible to infection with avian leukosis virus subgroup J, and the cloned Na+/H+ exchanger 1 confers susceptibility on the otherwise resistant host. New World quails are also susceptible to new avian leukosis virus subgroup J variants but resistant to subgroups A and B and weakly susceptible to subgroups C and D of avian sarcoma/leukosis virus due to obvious defects of the respective receptors. Our results suggest that the avian leukosis virus subgroup J could be transmitted to New World quails and establish a natural reservoir of circulating virus with a potential for further evolution. Since its spread in broiler chickens in China and Southeast Asia in 2000, ALV-J remains a major enzootic challenge for the poultry industry. Although the virus diversifies rapidly in the poultry, its spillover and circulation in wild bird species has been prevented by the resistance of most species to ALV-J. It is, nevertheless, important to understand the evolution of the virus and its potential host range in wild birds. Because resistance to avian retroviruses is due particularly to receptor incompatibility, we studied Na+/H+ exchanger 1, the receptor for ALV-J. In New World quails, we found a receptor compatible with virus entry, and we confirmed the susceptibilities of four New World quail species in vitro We propose that a prospective molecular epidemiology study be conducted to identify species with the potential to become reservoirs for ALV-J.

Dataset Information

Polyostotic osteosarcoma associated with avian leukosis virus infection in a captive bare-faced curassow (Crax fasciolata).

Background

Case presentation

Conclusions

Publications

Polyostotic osteosarcoma associated with avian leukosis virus infection in a captive bare-faced curassow (Crax fasciolata).

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