Dataset Information

Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis.

ABSTRACT:

Background

Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship.

Methods

We pooled data of 8686 COPD patients from 7 studies with a median length of 36-months of follow up. Using a longitudinal natural cubic spline regression model, we examined the dose-response relationship between body mass index (BMI) and the rate of decline in forced expiratory volume in one second (FEV₁) in patients with GOLD 1 and 2 disease, stratified by gender and adjusted for age, smoking status, and cohort effects.

Results

There was an inverse linear relationship between BMI and the rate of FEV₁ decline in GOLD Grades 1 and 2, which was modified by gender (p?2 reduced FEV₁ decline by 1.05 mL/year (95% CI 0.96, 1.14). However, in female patients, BMI status did not have a clinically meaningful impact on FEV₁ decline: an increase of baseline BMI by 1 kg/m² reduced FEV₁ decline by 0.16 ml/year (95% CI 0.11, 0.21). These gender-modified relationships were similar between GOLD 1 and 2 patients, and between current and former smokers.

Conclusion

In mild to moderate COPD, higher BMI was associated with a less rapid decline of FEV₁ in male patients whereas this association was minimal in females patients. This gender-specific BMI effect was independent of COPD severity and smoking status.

SUBMITTER: Chen W

PROVIDER: S-EPMC7891012 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis.

Chen Wenjia W Sadatsafavi Mohsen M FitzGerald J Mark JM Lynd Larry D LD Sin Don D DD

Respiratory research 20210218 1

<h4>Background</h4>Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship.<h4>Methods</h4>We pooled data of 8686 COPD patients from 7 studies with a median length of 36-months of follow up. Using a longitudinal natural cubic spline regression model, we examined the dose-response relationship between body mass index (BMI) and the rate of decline in forced expiratory volume ...[more]

PMID: 33602241

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Project description:Background: The gut microbiota is increasingly recognized as playing an important role in the development of obesity, but the influence of gender remains elusive. Using a large cohort of Chinese adults, our study aimed to identify differences in gut microbiota as a function of body mass index (BMI) and investigate gender specific features within these differences. Methods: Five hundred fifty-one participants were categorized as underweight, normal, overweight, or obese, based on their BMI. Fecal microbiome composition was profiled via 16S rRNA gene sequencing. Generalized linear model (GLM), BugBase, PICRUSt, and SPIEC-EASI were employed to assess the variabilities in richness, diversity, structure, organism-level microbiome phenotypes, molecular functions, and ecological networks of the bacterial community that associated with BMI and sex. Results: The bacterial community of the underweight group exhibited significantly higher alpha diversity than other BMI groups. When stratified by gender, the pattern of alpha diversity across BMI was maintained in females, but no significant difference in alpha diversity was detected among the BMI groups of males. An enrichment of Fusobacteria was observed in the fecal microbiota of obese males, while obese females demonstrated an increased relative abundance of Actinobacteria. Analysis of microbial community-level phenotypes revealed that underweight males tend to have more anaerobic and less facultatively anaerobic bacteria, indicating a reduced resistance to oxidative stress. Functionally, butyrate-acetoacetate CoA-transferase was enriched in obese individuals, which might favor energy accumulation. PhoH-like ATPase was found to be increased in male obese subjects, indicating a propensity to harvest energy. The microbial ecological network of the obese group contained more antagonistic microbial interactions as well as high-degree nodes. Conclusion: Using a large Chinese cohort, we demonstrated BMI-associated differences in gut microbiota composition, functions, and ecological networks, which were influenced by gender. Results in this area have shown variability across several independent studies, suggesting that further investigation is needed to understand the role of the microbiota in modulating host energy harvest and storage, and the impact of sex on these functions.

Dataset Information

Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis.

Background

Methods

Results

Conclusion

Publications

Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis.

Similar Datasets

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