Dataset Information

Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study.

ABSTRACT:

Background

Renal multiparametric magnetic resonance imaging (MRI) is a promising tool for diagnosis, prognosis, and treatment monitoring in kidney disease.

Purpose

To determine intrasubject test-retest repeatability of renal MRI measurements.

Study type

Prospective.

Population

Nineteen healthy subjects aged over 40?years.

Field strength/sequences

T₁ and T₂ mapping, R₂ * mapping or blood oxygenation level-dependent (BOLD) MRI, diffusion tensor imaging (DTI), and intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI), 2D phase contrast, arterial spin labelling (ASL), dynamic contrast enhanced (DCE) MRI, and quantitative Dixon for fat quantification at 3T.

Assessment

Subjects were scanned twice with ~1 week between visits. Total scan time was ~1?hour. Postprocessing included motion correction, semiautomated segmentation of cortex and medulla, and fitting of the appropriate signal model.

Statistical test

To assess the repeatability, a Bland-Altman analysis was performed and coefficients of variation (CoVs), repeatability coefficients, and intraclass correlation coefficients were calculated.

Results

CoVs for relaxometry (T₁ , T₂ , R₂ */BOLD) were below 6.1%, with the lowest CoVs for T₂ maps and highest for R₂ */BOLD. CoVs for all diffusion analyses were below 7.2%, except for perfusion fraction (F_P ), with CoVs ranging from 18-24%. The CoV for renal sinus fat volume and percentage were both around 9%. Perfusion measurements were most repeatable with ASL (cortical perfusion only) and 2D phase contrast with CoVs of 10% and 13%, respectively. DCE perfusion had a CoV of 16%, while single kidney glomerular filtration rate (GFR) had a CoV of 13%. Repeatability coefficients (RCs) ranged from 7.7-87% (lowest/highest values for medullary mean diffusivity and cortical F_P , respectively) and intraclass correlation coefficients (ICCs) ranged from -0.01 to 0.98 (lowest/highest values for cortical F_P and renal sinus fat volume, respectively).

Data conclusion

CoVs of most MRI measures of renal function and structure (with the exception of F_P and perfusion as measured by DCE) were below 13%, which is comparable to standard clinical tests in nephrology.

Level of evidence

2 TECHNICAL EFFICACY: Stage 1.

SUBMITTER: de Boer A

PROVIDER: S-EPMC7891585 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study.

de Boer Anneloes A Harteveld Anita A AA Stemkens Bjorn B Blankestijn Peter J PJ Bos Clemens C Franklin Suzanne L SL Froeling Martijn M Joles Jaap A JA Verhaar Marianne C MC van den Berg Nico N Hoogduin Hans H Leiner Tim T

Journal of magnetic resonance imaging : JMRI 20200416 3

<h4>Background</h4>Renal multiparametric magnetic resonance imaging (MRI) is a promising tool for diagnosis, prognosis, and treatment monitoring in kidney disease.<h4>Purpose</h4>To determine intrasubject test-retest repeatability of renal MRI measurements.<h4>Study type</h4>Prospective.<h4>Population</h4>Nineteen healthy subjects aged over 40 years.<h4>Field strength/sequences</h4>T<sub>1</sub> and T<sub>2</sub> mapping, R<sub>2</sub> * mapping or blood oxygenation level-dependent (BOLD) MRI, d ...[more]

PMID: 32297700

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Dataset Information

Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study.

Background

Purpose

Study type

Population

Field strength/sequences

Assessment

Statistical test

Results

Data conclusion

Level of evidence

Publications

Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study.

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