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Case Report: Successful Management of Conidiobolus Lamprauges Rhinitis in a Dog.

ABSTRACT: This is a case of Conidiobolus lamprauges rhinitis in a Goldendoodle, that was presented for evaluation of sneezing, coughing, lethargy, as well as right-sided epistaxis and clear ocular discharge. Computed tomography revealed a large amount of soft tissue within the right nasal passage that obscured the osseous turbinates from the right maxillary canine tooth to the right side of the choanae. Biopsies revealed eosinophilic granulomas with variable number of basophilic to negatively staining, septate, fungal hyphae with non-parallel walls and irregular branching that were subsequently determined to be Conidiobolus lamprauges via panfungal PCR and sequencing. Complete and sustained resolution of clinical disease was achieved after 75 days of systemic antifungal therapy. This report describes for the first time, important clinical features of a dog with nasal conidiobolomycosis that will facilitate its recognition, prognostication, and treatment in clinical practice.

SUBMITTER: Jaffey JA

PROVIDER: S-EPMC7892434 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Case Report: Successful Management of <i>Conidiobolus Lamprauges</i> Rhinitis in a Dog.

Jaffey Jared A JA Hostnik Eric T ET Hoffman Aline Rodrigues AR Jay Maureen M Ferguson Sylvia H SH Wiederhold Nathan P NP

Frontiers in veterinary science 20210205

This is a case of <i>Conidiobolus lamprauges</i> rhinitis in a Goldendoodle, that was presented for evaluation of sneezing, coughing, lethargy, as well as right-sided epistaxis and clear ocular discharge. Computed tomography revealed a large amount of soft tissue within the right nasal passage that obscured the osseous turbinates from the right maxillary canine tooth to the right side of the choanae. Biopsies revealed eosinophilic granulomas with variable number of basophilic to negatively stain ...[more]

PMID: 33614770

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Project description:Allergic Rhinitis is an immunological inflammatory response of the nasal mucosa to airborne allergens. Although Allergic Rhinitis is not a life-threatening disease, the symptoms of Allergic Rhinitis can be particularly bothersome and disruptive to a patient's sleep and overall quality of life. The coexistence of other allergic conditions like Asthma is very common. No satisfactory treatment is available in modern medicine for this disease. There is a need to search for satisfactory treatment available in another medical system. We present a case of Allergic Rhinitis that was successfully treated with Ayurvedic medicines. Allergic Rhinitis is characterized by watery nasal discharge, nasal obstruction, nasal mucosal pallor, sneezing, and itching in the eyes, palate, and pharynx. A 18-year-old female patient presented with complaints of sneezing (80-100/day), rhinorrhea (watery discharge from nose), heaviness in the head region, weakness, and loss of concentration hampering daily life activity for one year. The patient's clinical findings and symptoms were suggestive of Allergic Rhinitis, which is of perennial type. According to Ayurveda diagnosis was done as Vata-Kaphaj Pratishyay. Rajanyadi Churna was given to the patient for 15 days along with Guduchi Kwath (∼Guduchi decoction) followed by Shaman Snehapan (∼internal oleation) with Mahatiktak Ghrita. The patient experienced a reduction in all the symptoms after 15 days. Allergy markers i.e. Absolute Eosinophil Count reduced to 360 cells/cu mm from 704 cells/cu mm and eosinophils in CBC reduced to 4.1%. The primary complaint of sneezing was significantly reduced to 3-4 times/day after completing the treatment. Ayurvedic therapeutic interventions other than Nasya (∼Nasal oleation), and Dhoompana (∼medicated smoke) modalities showed encouraging results in managing Allergic Rhinitis in a short duration of time. This approach may be taken into consideration for further treatment and research work for Allergic Rhinitis.

Project description:BackgroundPenetrating thoracic injury is a type of critical illness with a high mortality rate, which often involves the heart, large blood vessels, and lungs. Penetrating cardiac injury is a very serious condition, and most patients die rapidly within minutes due to hemorrhagic shock and acute cardiac tamponade. Due to the critical condition and rapid development of this type of injury, most patients die before reaching the hospital. It is rare in clinical practice and difficult to treat.Case descriptionOur hospital recently admitted a case of penetrating cardiac injury. In this case, a 50-year-old male was admitted to the hospital following "a fall from a height [that] caused steel bar[s] to penetrate the chest cavity for 7 hours before he arrived at the hospital". The patient fell from a height of 3meters at a construction site, which caused 2 steel bars to penetrate his chest. The patient presented with symptoms such as chest pain, dyspnea, and apathy. Chest computed tomography suggested combined cardiopulmonary penetrating injury. Echocardiography suggested penetrating cardiac injury, and moderate pericardial effusion. After the patient was sent to the Emergency Department of our hospital, the relevant laboratory examinations and an emergency surgery were performed. The rescue team consisting of cardiac surgery, thoracic surgery, anesthesiology, emergency department, and imaging department specified the treatment plan. Under general anesthesia, cardiopulmonary bypass was performed via right femoral arteriovenous cannulation. The steel bars were removed, the left atrial posterior wall and ventricular septal perforation were repaired, and the great cardiac vein was sutured. Coronary artery bypass surgery was performed at the same time, and the anterolateral lung tissue of the left lower lobe was resected. Postoperative treatment was given to prevent against infection and improve cardiopulmonary function. The patient recovered well, and he was discharged from the hospital. The results of the follow-up 1 year after surgery were normal.ConclusionsTimely treatment and a reasonable operation mode is essential in treating this kind of trauma. A joint diagnosis and treatment by a multidisciplinary team can enable a comprehensive assessment of the condition to be made quickly and an optimal treatment plan to be formulated.

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Case Report: Successful Management of Conidiobolus Lamprauges Rhinitis in a Dog.

Publications

Case Report: Successful Management of <i>Conidiobolus Lamprauges</i> Rhinitis in a Dog.

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