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Diagnosis and successful management of a rare case of phaeohyphomycosis in a Doberman pinscher dog.

ABSTRACT: Skin affections in canines are common and their treatment depends upon the pathogens involved. Delayed or no response to traditional treatment indicates the involvement of unusual etiology or the multidrug resistance. This report describes the diagnosis and therapeutic management of a rare case of phaeohyphomycosis caused by Alternaria alternata complicated with Pseudomonas aeruginosa associated pyoderma in a Doberman pinscher dog. Identification of the etiological agents was based on microscopy and culture of the skin lesions and further confirmation by polymerase chain reaction (PCR) amplification. Treatment consisted of a combination of systemic antifungal and antibacterial drugs selected on the basis of in vitro antimicrobial susceptibility tests along with the tropical therapy. The report hightlights the need of studies on opportunistic fungi to better understand the associated risks, pathogenesis and optimal treatment of these uncommon infections.

SUBMITTER: Singh VK

PROVIDER: S-EPMC6361598 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Diagnosis and successful management of a rare case of phaeohyphomycosis in a Doberman pinscher dog.

Singh V K VK Kumar A A Pandey R P RP Yadav S K SK

Iranian journal of veterinary research 20180101 4

Skin affections in canines are common and their treatment depends upon the pathogens involved. Delayed or no response to traditional treatment indicates the involvement of unusual etiology or the multidrug resistance. This report describes the diagnosis and therapeutic management of a rare case of phaeohyphomycosis caused by <i>Alternaria alternata</i> complicated with <i>Pseudomonas aeruginosa</i> associated pyoderma in a Doberman pinscher dog. Identification of the etiological agents was based ...[more]

PMID: 30774675

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Project description:A 7-month-old Doberman Pinscher dog presented with progressive neurological signs and brain atrophy suggestive of a hereditary neurodegenerative disorder. The dog was euthanized due to the progression of disease signs. Microscopic examination of tissues collected at the time of euthanasia revealed massive accumulations of vacuolar inclusions in cells throughout the central nervous system, suggestive of a lysosomal storage disorder. A whole genome sequence generated with DNA from the affected dog contained a likely causal, homozygous missense variant in MAN2B1 that predicted an Asp104Gly amino acid substitution that was unique among whole genome sequences from over 4000 dogs. A lack of detectable α-mannosidase enzyme activity confirmed a diagnosis of a-mannosidosis. In addition to the vacuolar inclusions characteristic of α-mannosidosis, the dog exhibited accumulations of autofluorescent intracellular inclusions in some of the same tissues. The autofluorescence was similar to that which occurs in a group of lysosomal storage disorders called neuronal ceroid lipofuscinoses (NCLs). As in many of the NCLs, some of the storage bodies immunostained strongly for mitochondrial ATP synthase subunit c protein. This protein is not a substrate for α-mannosidase, so its accumulation and the development of storage body autofluorescence were likely due to a generalized impairment of lysosomal function secondary to the accumulation of α-mannosidase substrates. Thus, it appears that storage body autofluorescence and subunit c accumulation are not unique to the NCLs. Consistent with generalized lysosomal impairment, the affected dog exhibited accumulations of intracellular inclusions with varied and complex ultrastructural features characteristic of autophagolysosomes. Impaired autophagic flux may be a general feature of this class of disorders that contributes to disease pathology and could be a target for therapeutic intervention. In addition to storage body accumulation, glial activation indicative of neuroinflammation was observed in the brain and spinal cord of the proband.

Dataset Information

Diagnosis and successful management of a rare case of phaeohyphomycosis in a Doberman pinscher dog.

Publications

Diagnosis and successful management of a rare case of phaeohyphomycosis in a Doberman pinscher dog.

Similar Datasets

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