Dataset Information

Effect of normobaric hypoxic exercise on blood pressure in old individuals.

ABSTRACT:

Purpose

To test the hypothesis that the combination of endurance training and hypoxia leads to greater improvements in resting and exercise blood pressure in old sedentary individuals compared to endurance training only.

Methods

We randomly assigned 29 old overweight participants (age: 62?±?6 years, body mass index (BMI): 28.5?±?0.5 kg/m², 52% men) to single blind 8-week bicycle exercise in hypoxia (fraction of inspired oxygen (F_IO₂)?=?0.15) or normoxia (F_IO₂?=?0.21). Brachial blood pressure was measured at rest, during maximal incremental exercise testing, and during a 30 min constant work rate test, at baseline and after the training period.

Results

Work rate, heart rate and perceived exertion during training were similar in both groups, with lower oxygen saturation for participants exercising under hypoxia (88.7?±?1.5 vs. 96.2?±?1.2%, t(27)?=?-?13.04, p?2?=?0.01).

Conclusion

In old individuals hypoxia in addition to exercise does not have superior effects on office or exercise blood pressure compared to training in normoxia.

Trial registration number

ClinicalTrials.gov No. NCT02196623 (registered 22 July 2014).

SUBMITTER: Hein M

PROVIDER: S-EPMC7892684 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Effect of normobaric hypoxic exercise on blood pressure in old individuals.

Hein Markus M Chobanyan-Jürgens Kristine K Tegtbur Uwe U Engeli Stefan S Jordan Jens J Haufe Sven S

European journal of applied physiology 20201223 3

<h4>Purpose</h4>To test the hypothesis that the combination of endurance training and hypoxia leads to greater improvements in resting and exercise blood pressure in old sedentary individuals compared to endurance training only.<h4>Methods</h4>We randomly assigned 29 old overweight participants (age: 62 ± 6 years, body mass index (BMI): 28.5 ± 0.5 kg/m<sup>2</sup>, 52% men) to single blind 8-week bicycle exercise in hypoxia (fraction of inspired oxygen (F<sub>I</sub>O<sub>2</sub>) = 0.15) or nor ...[more]

PMID: 33355713

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Project description:Blood pressure regulation following spinal cord injury (SCI) is often compromised due to impaired vascular sympathetic control, leading to increased reliance on cardiovagal baroreflex sensitivity to maintain pressure. Whole-body exercise improves cardiovagal baroreflex sensitivity in uninjured individuals, though has not been explored in those with SCI. Our objective was to determine changes in cardiovagal baroreflex sensitivity following 6 months of high-intensity, whole-body exercise in individuals with SCI compared to lower-intensity, arms only exercise, or waitlist. This randomized controlled trial recruited individuals with SCI aged 18-40 years old. Sixty-one individuals were randomized, with 38 completing at least one cardiovagal baroreflex sensitivity assessment. Whole-body exercise was performed with hybrid functional electrical stimulation rowing prescribed as two to three times per week, for 30-60 minutes with a target heart rate of >75% of maximum. The arms only exercise group performed upper body rowing exercise with the same prescription as whole-body exercise. Waitlist controls were not enrolled in any explicit training regimen. After 6 months, those in arms only exercise or waitlist crossed over to whole-body exercise. Cardiovagal baroreflex sensitivity was assessed via the neck suction technique at baseline and at three-month intervals thereafter. Intention to treat analysis with a structured equation model demonstrated no significant effect of waitlist control or arms only exercise on cardiovagal baroreflex sensitivity. Whole-body exercise significantly improved cardiovagal baroreflex sensitivity at 6 months for those initially randomized (p = 0.03), as well as those who crossed over from arms only exercise or waitlist control (p = 0.03 for each). However, amount of exercise performed and aerobic gains (VO2max) each poorly correlated with increases in cardiovagal baroreflex sensitivity (R2<0.15). In post-hoc analyses, individuals with paraplegia made significantly greater gains in baroreflex sensitivity compared to those with tetraplegia (p = 0.02), though gains within this group were again poorly correlated to gains in aerobic capacity. Clinicaltrials.gov number NCT02139436.

Dataset Information

Effect of normobaric hypoxic exercise on blood pressure in old individuals.

Purpose

Methods

Results

Conclusion

Trial registration number

Publications

Effect of normobaric hypoxic exercise on blood pressure in old individuals.

Similar Datasets

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