Cryptobiosis-inspired assembly of "AND" logic gate platform for potential tumor-specific drug delivery.

ABSTRACT: Developing tumor-specific drug delivery systems with minimized off-target cargo leakage remains an enduring challenge. In this study, inspired from the natural cryptobiosis explored by certain organisms and stimuli-responsive polyphenol?metal coordination chemistry, doxorubicin (DOX)-conjugated gelatin nanoparticles with protective shells formed by complex of tannic acid and Fe^III (DG@TA-Fe^III NPs) were successfully developed as an "AND" logic gate platform for tumor-targeted DOX delivery. Moreover, benefiting from the well-reported photothermal conversion ability of TA-Fe^III complex, a synergistic tumor inhibition effect was confirmed by treating 4T1 tumor-bearing mice with DG@TA-Fe^III NPs and localized near-infrared (NIR) laser irradiation. As a proof of concept study, this work present a simple strategy for developing "AND" logic gate platforms by coating enzyme-degradable drug conjugates with detachable polyphenol?metal shells.

SUBMITTER: Zhou H 

PROVIDER: S-EPMC7893123 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature