Ontology highlight
ABSTRACT:
SUBMITTER: Bakalarz D
PROVIDER: S-EPMC7893125 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Bakalarz Dominik D Surmiak Marcin M Yang Xiaoxiao X Wójcik Dagmara D Korbut Edyta E Śliwowski Zbigniew Z Ginter Grzegorz G Buszewicz Grzegorz G Brzozowski Tomasz T Cieszkowski Jakub J Głowacka Urszula U Magierowska Katarzyna K Pan Zhixiang Z Wang Binghe B Magierowski Marcin M
Acta pharmaceutica Sinica. B 20200824 2
Metal-based carbon monoxide (CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative properties maintaining gastric mucosal integrity. We are interested in further development of metal-free CO-based therapeutics for oral administration. Thus, we examine the protective effect of representative CO prodrug, BW-CO-111, in rat models of gastric damage induced by necrotic ethanol or aspirin, a representative non-steroidal anti-inflammatory drug. Treatment effectiveness wa ...[more]