Ontology highlight
ABSTRACT:
SUBMITTER: Postma ED
PROVIDER: S-EPMC7897487 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nucleic acids research 20210201 3
The construction of microbial cell factories for sustainable production of chemicals and pharmaceuticals requires extensive genome engineering. Using Saccharomyces cerevisiae, this study proposes synthetic neochromosomes as orthogonal expression platforms for rewiring native cellular processes and implementing new functionalities. Capitalizing the powerful homologous recombination capability of S. cerevisiae, modular neochromosomes of 50 and 100 kb were fully assembled de novo from up to 44 tran ...[more]