Ontology highlight
ABSTRACT:
SUBMITTER: Cartmell C
PROVIDER: S-EPMC7898326 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Cartmell Christopher C Abou Fayad Antoine A Lynch Rosemary R Sharma Sunil V SV Hauck Nils N Gust Bertolt B Goss Rebecca J M RJM
Chembiochem : a European journal of chemical biology 20210115 4
A nonenzymatic Pictet-Spengler reaction has been postulated to give rise to a subset of naturally occurring uridyl peptide antibiotics (UPAs). Here, using a combination of strain engineering and synthetic chemistry, we demonstrate that Pictet-Spengler chemistry may be employed to generate even greater diversity in the UPAs. We use an engineered strain to afford access to meta-tyrosine containing pacidamycin 4. Pictet-Spengler diversification of this compound using a small series of aryl-aldehyde ...[more]