Dataset Information

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease.

ABSTRACT:

Purpose

To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia.

Methods

Data of 389 participants from the German DELCODE study (52% female, 69?±?6 years, mean Mini Mental State Score 29?±?1) were included. The sample was enriched with elderly at increased risk for Alzheimer's disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components.

Results

In fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The 'alcoholic beverages' PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n?=?60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant.

Conclusion

In line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.

SUBMITTER: Wesselman LMP

PROVIDER: S-EPMC7900077 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease.

Wesselman L M P LMP van Lent D Melo DM Schröder A A van de Rest O O Peters O O Menne F F Fuentes M M Priller J J Spruth E J EJ Altenstein S S Schneider A A Fließbach K K Roeske S S Wolfsgruber S S Kleineidam L L Spottke A A Pross V V Wiltfang J J Vukovich R R Schild A K AK Düzel E E Metzger C D CD Glanz W W Buerger K K Janowitz D D Perneczky R R Tatò M M Teipel S S Kilimann I I Laske C C Buchmann M M Ramirez A A Sikkes S A M SAM Jessen F F van der Flier W M WM Wagner M M

European journal of nutrition 20200529 2

<h4>Purpose</h4>To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia.<h4>Methods</h4>Data of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer's disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Medit ...[more]

PMID: 32472387

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Project description:Alzheimer's disease (AD) is one of the most common forms of dementia that has slowly negative impacts on memory and cognition. With the assistance of multimodal brain networks and graph-based analysis approaches, AD-related network disruptions support the hypothesis that AD can be identified as a dysconnectivity syndrome. However, as the recent emerging of individual-based morphological network research of AD, the utilization of multiple morphometric features may provide a broader horizon for locating the lesions. Therefore, the present study applied the newly proposed individual morphological brain network with five commonly used morphometric features (cortical thickness, regional volume, surface area, mean curvature, and fold index) to explore the topological aberrations and their relationship with cognitive functioning alterations in the early stage of AD. A total of 40 right-handed participants were selected from Open Access Series of Imaging Studies Database with 20 AD patients (age ranged from 70 to 79, CDR = 0.5) and 20 age/gender-matched healthy controls. The significantly affected connections (p < 0.05 with FDR correction) were observed across multiple regions, both enhanced and attenuated correlations, primarily related to the left entorhinal cortex (ENT). In addition, profoundly changed Mini Mental State Examination (MMSE) score and global efficiency (p < 0.05) were noted in the AD patients, as well as the pronounced inter-group distinctions of betweenness centrality, global and local efficiency (p < 0.05) in the higher MMSE score zone (28-30), which indicating the potential role of graphic properties in determination of early-stage AD patients. Moreover, the reservations (regions in the occipital and frontal lobes) and alterations (regions in the right temporal lobe and cingulate cortex) of hubs were also detected in the AD patients. Overall, the findings further confirm the selective AD-related disruptions in morphological brain networks and also suggest the feasibility of applying the morphological graphic properties in the discrimination of early-stage AD patients.

Dataset Information

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease.

Purpose

Methods

Results

Conclusion

Publications

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer's disease.

Similar Datasets

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