Dataset Information

Interfacial engineering of Bi₂S₃/Ti₃C₂T_x MXene based on work function for rapid photo-excited bacteria-killing.

ABSTRACT: In view of increasing drug resistance, ecofriendly photoelectrical materials are promising alternatives to antibiotics. Here we design an interfacial Schottky junction of Bi₂S₃/Ti₃C₂T_x resulting from the contact potential difference between Ti₃C₂T_x and Bi₂S₃. The different work functions induce the formation of a local electrophilic/nucleophilic region. The self-driven charge transfer across the interface increases the local electron density on Ti₃C₂T_x. The formed Schottky barrier inhibits the backflow of electrons and boosts the charge transfer and separation. The photocatalytic activity of Bi₂S₃/Ti₃C₂T_x intensively improved the amount of reactive oxygen species under 808?nm near-infrared radiation. They kill 99.86% of Staphylococcus aureus and 99.92% of Escherichia coli with the assistance of hyperthermia within 10?min. We propose the theory of interfacial engineering based on work function and accordingly design the ecofriendly photoresponsive Schottky junction using two kinds of components with different work functions to effectively eradicate bacterial infection.

SUBMITTER: Li J

PROVIDER: S-EPMC7900204 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Interfacial engineering of Bi2S3/Ti3C2Tx MXene based on work function for rapid photo-excited bacteria-killing.

Li Jianfang J Li Zhaoyang Z Liu Xiangmei X Li Changyi C Zheng Yufeng Y Yeung Kelvin Wai Kwok KWK Cui Zhenduo Z Liang Yanqin Y Zhu Shengli S Hu Wenbin W Qi Yajun Y Zhang Tianjin T Wang Xianbao X Wu Shuilin S

Nature communications 20210222 1

In view of increasing drug resistance, ecofriendly photoelectrical materials are promising alternatives to antibiotics. Here we design an interfacial Schottky junction of Bi2S3/Ti3C2Tx resulting from the contact potential difference between Ti3C2Tx and Bi2S3. The different work functions induce the formation of a local electrophilic/nucleophilic region. The self-driven charge transfer ac ...[more]

PMID: 33619276

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Project description:Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripotent stem cell derived cardiomyocytes (iCMs) is developed for cardiac tissue engineering applications. The constructs are fabricated by 3D printing conductive titanium carbide (Ti3C2Tx) MXene in pre-designed patterns on polyethylene glycol (PEG) hydrogels, using aerosol jet printing, at a cell-level resolution and then seeded with iCMs and cultured for one week with no signs of cytotoxicity. The results presented in this work illustrate the vital role of 3D-printed Ti3C2Tx MXene on aligning iCMs with a significant increase in MYH7, SERCA2, and TNNT2 expressions, and with an improved synchronous beating as well as conduction velocity. This study demonstrates that 3D printed Ti3C2Tx MXene can potentially be used to create physiologically relevant cardiac patches for the treatment of MI. STATEMENT OF SIGNIFICANCE: As cardiovascular diseases and specifically myocardial infarction (MI) continue to be the leading cause of death worldwide, it is critical that new clinical interventions be developed. Tissue engineered cardiac patches have shown significant potential as clinical therapeutics to promote recovery following MI. Unfortunately, current constructs lack the ordered structure and electroconductivity of native human heart. In this study, we engineered a composite construct that can provide both conductive and topographical cues for human induced pluripotent stem cell derived cardiomyocytes. By 3D printing conductive Ti3C2Tx MXene in pre-designed patterns on polyethylene glycol hydrogels, using aerosol jet printing, at a cell-level resolution, we developed tissue engineered patches that have the potential for providing a new clinical therapeutic to combat cardiovascular disease.

Dataset Information

Interfacial engineering of Bi₂S₃/Ti₃C₂T_x MXene based on work function for rapid photo-excited bacteria-killing.

Publications

Interfacial engineering of Bi<sub>2</sub>S<sub>3</sub>/Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene based on work function for rapid photo-excited bacteria-killing.

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