Ontology highlight
ABSTRACT:
SUBMITTER: Mengel-From J
PROVIDER: S-EPMC7900237 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Mengel-From Jonas J Lindahl-Jacobsen Rune R Nygaard Marianne M Soerensen Mette M Ørstavik Karen Helene KH Hertz Jens Michael JM Andersen-Ranberg Karen K Tan Qihua Q Christensen Kaare K
Scientific reports 20210222 1
Mosaicism in blood varies with age, and cross-sectional studies indicate that for women, skewness of X-chromosomal mosaicism increases with age. This pattern could, however, also be due to less X-inactivation in more recent birth cohorts. Skewed X-chromosome inactivation was here measured longitudinally by the HUMARA assay in 67 septuagenarian and octogenarian women assessed at 2 time points, 10 years apart, and in 10 centenarian women assessed at 2 time points, 2-7 years apart. Skewed X-chromos ...[more]