Dataset Information

UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.

ABSTRACT: An efficient uncoupling process is generally considered to have a protective effect on the aging muscle by slowing down its age-related decay. Genetic polymorphisms in the Uncoupling Protein 3 (UCP3) gene, whose product is mainly expressed in skeletal muscle, were suggested to be associated with hand grip (HG) performances in elderly populations. Considering the population specificity of the quality of aging, we aimed to add further support to this evidence by analyzing the association between four SNPs in the UCP3 gene and relative haplotypes in two large cohorts of middle aged (N=708) and oldest old Danes (N=908). We found that the variability at rs1685354 and rs11235972 was associated with HG levels both at single and haplotypic level in both cohorts. Furthermore, taking advantage of large cohort and period survival data of the oldest cohort, we tested the association of each SNP with survival at 10years from the baseline visit. Interestingly, we found that allele A at rs11235972, associated in this cohort with lowest HG scores, influences also the survival patterns, with people carrying this allele showing higher mortality rates. On the whole, our work supports the role of UCP3 gene in functional status and survival at old age.

SUBMITTER: Dato S

PROVIDER: S-EPMC3629378 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.

Dato Serena S Soerensen Mette M Montesanto Alberto A Lagani Vincenzo V Passarino Giuseppe G Christensen Kaare K Christiansen Lene L

Mechanisms of ageing and development 20120626 8

An efficient uncoupling process is generally considered to have a protective effect on the aging muscle by slowing down its age-related decay. Genetic polymorphisms in the Uncoupling Protein 3 (UCP3) gene, whose product is mainly expressed in skeletal muscle, were suggested to be associated with hand grip (HG) performances in elderly populations. Considering the population specificity of the quality of aging, we aimed to add further support to this evidence by analyzing the association between f ...[more]

PMID: 22743239

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Project description:BACKGROUND:Transient cognitive impairment is common in adult patients of all ages following anaesthesia and surgery. Apolipoprotein E (APOE) ?4 carriers may have a larger deterioration in short-term cognitive function after major surgery compared with APOE ?4 noncarriers. OBJECTIVES:The aim was to examine the effect of APOE ?4 on the association between exposure to surgery and anaesthesia, and subsequent cognitive functioning. A more pronounced deterioration in cognitive function in APOE ?4 carriers was hypothesised. DESIGN:An observational cross-sectional and a 6 to 10 years longitudinal twin cohort design. SETTING:Survey and register study of 2936 Danish twins aged 45 to 92 years. MAIN OUTCOME MEASURES:Cognitive function was assessed using five age-sensitive cognitive tests. In the cross-sectional study, we compared twins exposed to surgery with a reference group (unexposed). Linear regression models were used adjusting for sex and age and stratified by APOE ?4 carrier status. In the longitudinal cognitive follow-up study 1671 twins participated. Intrapair analyses were also performed using 70 same-sexed twin pairs concordant for APOE ?4 carrier status, but discordant for major surgery. RESULTS:APOE ?4 carriers had lower cognitive scores compared with noncarriers, and this was statistically significant in elderly twins 70+ years of age (mean difference, -0.67; 95% CI, -1.14 to -0.17). There was no significant impact on cognitive function after surgery according to APOE ?4 carrier status in the cross-sectional study. Similarly, there was no APOE ?4 modification in the longitudinal study. Also, in the intrapair analyses no evidence was found of lower cognitive score after major surgery compared with the nonexposed cotwins among APOE ?4 carriers. CONCLUSION:No evidence was found of more pronounced long-term deterioration in cognitive function after surgery among APOE ?4 carriers, but elderly APOE ?4 carriers in general performed worse on the cognitive tests than noncarriers.

Dataset Information

UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.

Publications

UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.

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