Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC7900595 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Li Mark M Yamada Satsuki S Shi Ao A Singh Raman Deep RD Rolland Tyler J TJ Jeon Ryounghoon R Lopez Natalia N Shelerud Lukas L Terzic Andre A Behfar Atta A
Stem cells translational medicine 20201024 3
To optimize the regenerative proficiency of stem cells, a cardiopoietic protein-based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment of ischemic heart failure. Streamlining the inductors of cardiopoiesis would address the resource intensive nature of the current stem cell enhancement protocol. To this end, the microencapsulated-modified-mRNA (M<sup>3</sup> RNA) technique was here applied to introduce early cardiogenic genes into ...[more]