Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC7901769 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zhang Zhe Z Luo Shuo S Barbosa Guilherme Oliveira GO Bai Meirong M Kornberg Thomas B TB Ma Dengke K DK
PLoS genetics 20210201 2
Dysregulation of collagen production and secretion contributes to aging and tissue fibrosis of major organs. How procollagen proteins in the endoplasmic reticulum (ER) route as specialized cargos for secretion remains to be fully elucidated. Here, we report that TMEM39, an ER-localized transmembrane protein, regulates production and secretory cargo trafficking of procollagen. We identify the C. elegans ortholog TMEM-39 from an unbiased RNAi screen and show that deficiency of tmem-39 leads to str ...[more]