Ontology highlight
ABSTRACT:
SUBMITTER: Bharucha N
PROVIDER: S-EPMC3814151 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Bharucha Nike N Liu Yang Y Papanikou Effrosyni E McMahon Conor C Esaki Masatoshi M Jeffrey Philip D PD Hughson Frederick M FM Glick Benjamin S BS
Molecular biology of the cell 20130904 21
During the budding of coat protein complex II (COPII) vesicles from transitional endoplasmic reticulum (tER) sites, Sec16 has been proposed to play two distinct roles: negatively regulating COPII turnover and organizing COPII assembly at tER sites. We tested these ideas using the yeast Pichia pastoris. Redistribution of Sec16 to the cytosol accelerates tER dynamics, supporting a negative regulatory role for Sec16. To evaluate a possible COPII organization role, we dissected the functional region ...[more]