Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC7902394 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Yuan Yue Y Raj Piyush P Zhang Jia J Siddhanta Soumik S Barman Ishan I Bulte Jeff W M JWM
Angewandte Chemie (International ed. in English) 20210126 8
Olsalazine (Olsa) is a broad-spectrum anti-cancer agent acting as a DNA-methylation inhibitor. When conjugated to 2-cyano-6-aminobenzothiazole and a peptide substrate specific for the tumor-overexpressed enzyme furin, it can self-assemble into nanoparticles that can be detected by chemical-exchange saturation-transfer magnetic-resonance imaging (CEST MRI). We report here that these nano-assemblies can also be detected with high specificity in furin-overexpressing tumor cells by Raman spectroscop ...[more]