Dataset Information
Risk levels of herb-induced liver injury in Korea: from a meta-analysis.
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ABSTRACT: Background
As the use of herbal medicines increased worldwide, there has been concern about the risk of herb-induced liver injury (HILI). Many clinical studies have assessed the risk of HILI in Korea.Methods
Therefore, we conducted a meta-analysis of the incidence of HILI in Korea, by analyzing nine clinical studies. These involved 8625 participants (3274 males; 5351 females), including 436 outpatients (three studies) and 8189 inpatients (six studies).Results
As a result, the overall incidence of HILI in Korea was 0.49% (95% CI 0.33-0.74%), and it was 0.57% in males and 0.30% in females. We found a similar incidence of HILI in prospective (0.51%) and retrospective (0.50%) studies. The incidence of HILI was higher in inpatients (0.62%) than outpatients (0.03%).Conclusion
Although there are limitations regarding study quality and the number of participants, we systematically estimated the risk of HILI in Korea. We anticipate this study would be a helpful information for prescribing herbal medicines and researching the safety of herbs.
SUBMITTER: Lee NH
PROVIDER: S-EPMC7903345 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Risk levels of herb-induced liver injury in Korea: from a meta-analysis.
Integrative medicine research 20201205 3
<h4>Background</h4>As the use of herbal medicines increased worldwide, there has been concern about the risk of herb-induced liver injury (HILI). Many clinical studies have assessed the risk of HILI in Korea.<h4>Methods</h4>Therefore, we conducted a meta-analysis of the incidence of HILI in Korea, by analyzing nine clinical studies. These involved 8625 participants (3274 males; 5351 females), including 436 outpatients (three studies) and 8189 inpatients (six studies).<h4>Results</h4>As a result, ...[more]