Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC7903351 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Kim Soyeon S Kwon Mira M Hwang Yiseul Y Yoon Junghyun J Park Sangwook S Kang Ho Chul HC
iScience 20210206 3
Stress-coupled NEDDylation potentially regulates the aggregation of nuclear proteins, which could protect the nuclear ubiquitin-proteasome system from proteotoxic stress. However, it remains unclear how NEDDylation controls protein-aggregation responses to diverse stress conditions. Here, we identified HDAC6 as a direct NEDD8-binding partner that regulates the formation of aggresome-like bodies (ALBs) containing NEDDylated cytosolic protein aggregates during ubiquitin stress. HDAC6 colocalizes w ...[more]