Dataset Information

Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated Coronavirus Disease 2019 (COVID-19) is a public health emergency. Acute kidney injury (AKI) is a common complication in hospitalized patients with COVID-19 although mechanisms underlying AKI are yet unclear. There may be a direct effect of SARS-CoV-2 virus on the kidney; however, there is currently no data linking SARS-CoV-2 viral load (VL) to AKI. We explored the association of SARS-CoV-2 VL at admission to AKI in a large diverse cohort of hospitalized patients with COVID-19.

Methods and findings

We included patients hospitalized between March 13th and May 19th, 2020 with SARS-CoV-2 in a large academic healthcare system in New York City (N = 1,049) with available VL at admission quantified by real-time RT-PCR. We extracted clinical and outcome data from our institutional electronic health records (EHRs). AKI was defined by KDIGO guidelines. We fit a Fine-Gray competing risks model (with death as a competing risk) using demographics, comorbidities, admission severity scores, and log10 transformed VL as covariates and generated adjusted hazard ratios (aHR) and 95% Confidence Intervals (CIs). VL was associated with an increased risk of AKI (aHR = 1.04, 95% CI: 1.01-1.08, p = 0.02) with a 4% increased hazard for each log10 VL change. Patients with a viral load in the top 50th percentile had an increased adjusted hazard of 1.27 (95% CI: 1.02-1.58, p = 0.03) for AKI as compared to those in the bottom 50th percentile.

Conclusions

VL is weakly but significantly associated with in-hospital AKI after adjusting for confounders. This may indicate the role of VL in COVID-19 associated AKI. This data may inform future studies to discover the mechanistic basis of COVID-19 associated AKI.

SUBMITTER: Paranjpe I

PROVIDER: S-EPMC7904214 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study.

Paranjpe Ishan I Chaudhary Kumardeep K Johnson Kipp W KW Jaladanki Suraj K SK Zhao Shan S De Freitas Jessica K JK Pujdas Elisabet E Chaudhry Fayzan F Bottinger Erwin P EP Levin Matthew A MA Fayad Zahi A ZA Charney Alexander W AW Houldsworth Jane J Cordon-Cardo Carlos C Glicksberg Benjamin S BS Nadkarni Girish N GN

PloS one 20210224 2

<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated Coronavirus Disease 2019 (COVID-19) is a public health emergency. Acute kidney injury (AKI) is a common complication in hospitalized patients with COVID-19 although mechanisms underlying AKI are yet unclear. There may be a direct effect of SARS-CoV-2 virus on the kidney; however, there is currently no data linking SARS-CoV-2 viral load (VL) to AKI. We explored the association of SARS-CoV-2 VL at ad ...[more]

PMID: 33626098

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Dataset Information

Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study.

Background

Methods and findings

Conclusions

Publications

Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study.

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