Ontology highlight
ABSTRACT:
SUBMITTER: Liaw K
PROVIDER: S-EPMC7904646 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Liaw Kevin K Sharma Rishi R Sharma Anjali A Salazar Sebastian S Appiani La Rosa Santiago S Kannan Rangaramanujam M RM
Journal of controlled release : official journal of the Controlled Release Society 20201205
Novel delivery strategies are necessary to effectively address glioblastoma without systemic toxicities. Triptolide is a therapy derived from the thunder god vine that has shown potent anti-proliferative and immunosuppressive properties but exhibits significant adverse systemic effects. Dendrimer-based nanomedicines have shown great potential for clinical translation of systemic therapies targeting neuroinflammation and brain tumors. Here we present a novel dendrimer-triptolide conjugate that sp ...[more]