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Leveraging synthetic chlorins for bio-imaging applications.

ABSTRACT: Synthetic chlorins are not only fluorescent, the modulation of the tetrapyrrole system can also chelate metal ions. Conjugation of linkers at their pyrrolidines allows for conjugation to bio-molecules to create target specificity. By altering these chemo-photophysical properties, this work facilitates the use of chlorins in fluorescent imaging and positron emission tomography (PET).

SUBMITTER: Hernandez-Gil J

PROVIDER: S-EPMC7907923 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Leveraging synthetic chlorins for bio-imaging applications.

Hernández-Gil Javier J Lewis Jason S JS Reiner Thomas T Drain Charles Michael CM Gonzales Junior J

Chemical communications (Cambridge, England) 20201001 83

Synthetic chlorins are not only fluorescent, the modulation of the tetrapyrrole system can also chelate metal ions. Conjugation of linkers at their pyrrolidines allows for conjugation to bio-molecules to create target specificity. By altering these chemo-photophysical properties, this work facilitates the use of chlorins in fluorescent imaging and positron emission tomography (PET). ...[more]

PMID: 32945820

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