Ontology highlight
ABSTRACT:
SUBMITTER: Radvak P
PROVIDER: S-EPMC7910538 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Radvak Peter P Kosikova Martina M Kuo Yuan-Chia YC Li Xing X Garner Richard R Schmeisser Falko F Kosik Ivan I Ye Zhiping Z Weir Jerry P JP Yewdell Jonathan W JW Xie Hang H
NPJ vaccines 20210226 1
Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic. Here, we assess the immunogenicity and efficacy of a highly pathogenic avian influenza (HPAI) A/Guangdong/17SF003/2016 (GD/16)-extracted hemagglutinin (eHA) vaccine. GD/16 eHA induces robust H7-specific antibody responses in mice with a marked adjuvant antigen-sparing effect. Mice immuniz ...[more]