Ontology highlight
ABSTRACT:
SUBMITTER: Pham PN
PROVIDER: S-EPMC7911045 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Pham Phuong Ngoc PN Huličiak Maroš M Biedermannová Lada L Černý Jiří J Charnavets Tatsiana T Fuertes Gustavo G Herynek Štěpán Š Kolářová Lucie L Kolenko Petr P Pavlíček Jiří J Zahradník Jiří J Mikulecky Pavel P Schneider Bohdan B
Viruses 20210127 2
Engineered small non-antibody protein scaffolds are a promising alternative to antibodies and are especially attractive for use in protein therapeutics and diagnostics. The advantages include smaller size and a more robust, single-domain structural framework with a defined binding surface amenable to mutation. This calls for a more systematic approach in designing new scaffolds suitable for use in one or more methods of directed evolution. We hereby describe a process based on an analysis of pro ...[more]