Ontology highlight
ABSTRACT:
SUBMITTER: Shiraki M
PROVIDER: S-EPMC7911745 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Shiraki Mayuka M Kadowaki Saori S Kadowaki Tomonori T Kawamoto Norio N Ohnishi Hidenori H
Children (Basel, Switzerland) 20210122 2
Behcet's disease (BD) is a chronic inflammatory disease with multisystemic involvement. Its etiology is considered to involve complex environmental and genetic factors. Several susceptibility genes for BD, such as human leukocyte antigen (HLA)-A26, <i>IL23R-IL12RB2</i>, <i>IL10</i> and <i>ERAP1</i>, in addition to the well-studied HLA-B51, were mainly identified by genome-wide association studies. A heterozygous mutation in <i>TNFAIP3</i>, which leads to A20 haploinsufficiency, was found to caus ...[more]