Ontology highlight
ABSTRACT:
SUBMITTER: Chamaillard M
PROVIDER: S-EPMC3040328 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Chamaillard Mathias M Dessein Rodrigue R
World journal of gastroenterology 20110201 5
Antimicrobial peptides, including defensins, are essential effectors in host defence and in the maintenance of immune homeostasis. Clinical studies have linked the defective expression of both α- and β-defensin to the reduced killing of certain microorganisms by the intestinal mucosa of patients suffering from ileal and colonic Crohn's disease (CD), respectively. Only recently have the events leading to defective expression of defensins in CD been further elucidated, and are discussed herein. Th ...[more]