Control of Capsid Transformations during Reovirus Entry.
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ABSTRACT:
SUBMITTER: Gummersheimer SL
PROVIDER: S-EPMC7911961 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Control of Capsid Transformations during Reovirus Entry.
Gummersheimer Stephanie L SL Snyder Anthony J AJ Danthi Pranav P
Viruses 20210121 2
Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate. The metastable particle undergoes further remodeling to generate an entry-capable form that delivers the genome-containing inner capsid, or core, into the cytoplasm. In this review, we highlight capsid proteins and the intricacies of their interactions that c ...[more]
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