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Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12.


ABSTRACT: One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B-C (2,3) and three new ?-pyrone derivatives, diaporpyrones A-C (4-6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC50 values of 21.5 and 12.5 ?M, respectively.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7912375 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus <i>Diaporthe</i> sp. QYM12.

Chen Yan Y   Zou Ge G   Yang Wencong W   Zhao Yingying Y   Tan Qi Q   Chen Lin L   Wang Jinmei J   Ma Changyang C   Kang Wenyi W   She Zhigang Z  

Marine drugs 20210124 2


One new diterpenoid, diaporpenoid A (<b>1</b>), two new sesquiterpenoids, diaporpenoids B-C (<b>2</b>,<b>3</b>) and three new <i>α</i>-pyrone derivatives, diaporpyrones A-C (<b>4</b>-<b>6</b>) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus <i>Diaporthe</i> sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a compari  ...[more]

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