Unknown

Dataset Information

0

Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3.


ABSTRACT: Eight new compounds, including two sambutoxin derivatives (1-2), two highly oxygenated cyclopentenones (7-8), four highly oxygenated cyclohexenones (9-12), together with four known sambutoxin derivatives (3-6), were isolated from semimangrove endophytic fungus Talaromyces sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis, 13C NMR calculation, and DP4+ analysis. In bioassays, compounds 1-5 displayed better α-glucosidase inhibitory activity than the positive control 1-deoxynojirimycin (IC50 = 80.8 ± 0.3 μM), and the IC50 value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM.

SUBMITTER: Yang W 

PROVIDER: S-EPMC8465095 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6723402 | biostudies-literature
| S-EPMC4882560 | biostudies-literature
| S-EPMC5149032 | biostudies-literature
| S-EPMC4446620 | biostudies-literature
| S-EPMC7037671 | biostudies-literature
| S-EPMC9503262 | biostudies-literature
| S-EPMC5913051 | biostudies-literature
| S-EPMC6154586 | biostudies-literature
| S-EPMC5793060 | biostudies-literature
| S-EPMC7912375 | biostudies-literature