Dataset Information

The Effect of Omega-3 Fatty Acid Supplementation on Serum Adipocytokines, Lipid Profile and Biochemical Markers of Inflammation in Recreational Runners.

ABSTRACT:

Background

The study aimed to evaluate the effects of a 3-week ?-3 PUFA supplementation on serum adipocytokines (i.e., adiponectin, leptin), neuregulin-4 (NRG4) and erythrocyte omega-3 (?-3) fatty acid content, as well as the blood antioxidant defense capacity in non-elite endurance runners.

Methods

Twenty-four runners were randomized into two groups: the supplemented group, who received omega free fatty acids extract containing 142 mg of EPA, 267 mg of DHA, 12 mg of vitamin E and 5 µg of vitamin D, each administrated at a dose of six capsules twice a day for three weeks, or the placebo group. Venous blood samples were withdrawn at the start and at the end of the study protocols to estimate serum biochemical variables.

Results

A significantly higher ?-3 index and lower AA/EPA ratio was observed after ?-3 PUFA compared to pre-supplementation levels (p < 0.001 and p < 0.001, respectively). An increase in baseline adiponectin and NRG4 levels, as well as a decrease of leptin concentration and lipid profile improvement, were observed in subjects after a ?-3 PUFA diet. The increased ?-3 index had a significant effect on TNF? levels and a serum marker of antioxidant defense.

Conclusions

The ?-3 PUFA extract with added vitamin E and D supplementation may have a positive effect on the function of the adipocyte tissue, as well as the ability to prevent cardiovascular complications in athletes.

SUBMITTER: Zebrowska A

PROVIDER: S-EPMC7912656 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

The Effect of Omega-3 Fatty Acid Supplementation on Serum Adipocytokines, Lipid Profile and Biochemical Markers of Inflammation in Recreational Runners.

Żebrowska Aleksandra A Hall Barbara B Stolecka-Warzecha Anna A Stanula Arkadiusz A Sadowska-Krępa Ewa E

Nutrients 20210129 2

<h4>Background</h4>The study aimed to evaluate the effects of a 3-week ω-3 PUFA supplementation on serum adipocytokines (i.e., adiponectin, leptin), neuregulin-4 (NRG4) and erythrocyte omega-3 (ω-3) fatty acid content, as well as the blood antioxidant defense capacity in non-elite endurance runners.<h4>Methods</h4>Twenty-four runners were randomized into two groups: the supplemented group, who received omega free fatty acids extract containing 142 mg of EPA, 267 mg of DHA, 12 mg of vitamin E and ...[more]

PMID: 33573042

Similar Datasets

Project description:BACKGROUND:The beneficial adaptation of skeletal muscle function to strenuous exercise is partially attributable to the improvement of vitamin D status. The present study aimed to evaluate the effects of a 3-week vitamin D supplementation on serum 25(OH)D levels and skeletal muscle biomarkers (i.e. troponin, myoglobin, creatine kinase and lactic dehydrogenase) of endurance runners. METHODS:A double-blind placebo-controlled study design was used and vitamin D supplementation was compared to a non-treatment control group. Twenty-four runners, competitors of the ultra-marathons held during the National Running Championships, were randomly assigned into two groups supplemented with the dose of 2000?IU vitamin D or placebo for three weeks. All subjects participated in three exercise protocols: (a) incremental exercise test (to determine the maximum oxygen uptake and the intensity of eccentric exercise), (b) eccentric exercise before and (c) after two dietary protocols. Venous blood samples were drawn at rest, immediately after the exercise and after 1?h and 24?h of recovery in order to estimate serum 25(OH)D levels, skeletal muscle biomarkers, proinflammatory cytokines and tumor necrosis factor-alpha (TNF-?) levels. A two-way ANOVA was used to test main effects and their interactions and Pearson correlation coefficients were analyzed to determine the effects of inter-variable relationships. RESULTS:Significant differences between pre- and post-intervention in baseline 25(OH)D levels were observed (34.9?±?4.7 versus 40.3?±?4.9?ng/ml, p?= 0.02) in supplemented group. A higher post intervention 25(OH)D level was observed after vitamin D diet compared to placebo (40.3?±?4.9 versus 31.8?±?4.2?ng/mL, respectively; p?< 0.05). The vitamin D supplementation decreased post-exercise (TN max) and 1?h post-exercise troponin (p?= 0.004, p?=?0.03, respectively), 1?h post-exercise myoglobin concentration (p?=?0.01) and TNF-? levels(p?<?0.03). 24?h post exercise creatine kinase activity was significantly lower in supplemented group compared to placebo (p?<?0.05). A negative correlation was observed between post exercise 25(OH)D levels and myoglobin levels (r?=?-?0.57; p?=?0.05), and 25(OH)D levels and TNF? (r?=?-?0.58; p?=?0.05) in vitamin D supplemented group. CONCLUSIONS:Three weeks of vitamin D supplementation had a positive effect on serum 25(OH)D levels in endurance trained runners and it caused a marked decrease in post-exercise biomarkers levels. We concluded that vitamin D supplementation might play an important role in prevention of skeletal muscle injuries following exercise with eccentric muscle contraction in athletes.

Dataset Information

The Effect of Omega-3 Fatty Acid Supplementation on Serum Adipocytokines, Lipid Profile and Biochemical Markers of Inflammation in Recreational Runners.

Background

Methods

Results

Conclusions

Publications

The Effect of Omega-3 Fatty Acid Supplementation on Serum Adipocytokines, Lipid Profile and Biochemical Markers of Inflammation in Recreational Runners.

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