Ontology highlight
ABSTRACT:
SUBMITTER: Zhang ZD
PROVIDER: S-EPMC7912776 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhang Zhengdong D ZD Milman Sofiya S Lin Jhih-Rong JR Wierbowski Shayne S Yu Haiyuan H Barzilai Nir N Gorbunova Vera V Ladiges Warren C WC Niedernhofer Laura J LJ Suh Yousin Y Robbins Paul D PD Vijg Jan J
Nature metabolism 20200727 8
Ageing is the greatest risk factor for most common chronic human diseases, and it therefore is a logical target for developing interventions to prevent, mitigate or reverse multiple age-related morbidities. Over the past two decades, genetic and pharmacologic interventions targeting conserved pathways of growth and metabolism have consistently led to substantial extension of the lifespan and healthspan in model organisms as diverse as nematodes, flies and mice. Recent genetic analysis of long-li ...[more]