Longevity pathways are associated with human ovarian ageing.
Ontology highlight
ABSTRACT:
SUBMITTER: Smits MAJ
PROVIDER: S-EPMC8126403 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Longevity pathways are associated with human ovarian ageing.
Smits Myrthe A J MAJ Janssens Georges E GE Goddijn Mariëtte M Hamer Geert G Houtkooper Riekelt H RH Mastenbroek Sebastiaan S
Human reproduction open 20210516 2
<h4>Study question</h4>Are genes known to be involved in somatic cell ageing, particularly related to longevity pathways, associated with the accelerated ageing process of the ovary?<h4>Summary answer</h4>Growth, metabolism, and cell-cycle progression-related pathways that are involved in somatic cell ageing are also associated with ovarian ageing.<h4>What is known already</h4>Ovarian ageing is characterized by a gradual decline in ovarian follicle quantity, a decline in oocyte quality, and lowe ...[more]
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