Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells.
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ABSTRACT:
SUBMITTER: Saito MK
PROVIDER: S-EPMC7912798 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells.
Children (Basel, Switzerland) 20210201 2
Autoinflammatory diseases are a disease entity caused by the dysregulation of innate immune cells. Typical autoinflammatory diseases are monogenic disorders and often very rare. As a result, there is a relative lack of understanding of the pathogenesis, poor diagnosis and little available treatment. Induced pluripotent stem (iPS) cells are a new technology being applied to in vitro disease modeling. These models are especially useful for the analysis of rare and intractable diseases including au ...[more]
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