Ontology highlight
ABSTRACT:
SUBMITTER: Chen FK
PROVIDER: S-EPMC4470196 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Chen Fred K FK McLenachan Samuel S Edel Michael M Da Cruz Lyndon L Coffey Peter J PJ Mackey David A DA
Journal of clinical medicine 20141219 4
For many decades, we have relied on immortalised retinal cell lines, histology of enucleated human eyes, animal models, clinical observation, genetic studies and human clinical trials to learn more about the pathogenesis of retinal diseases and explore treatment options. The recent availability of patient-specific induced pluripotent stem cells (iPSC) for deriving retinal lineages has added a powerful alternative tool for discovering new disease-causing mutations, studying genotype-phenotype rel ...[more]