Ontology highlight
ABSTRACT:
SUBMITTER: Bezrukov F
PROVIDER: S-EPMC7913683 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Bezrukov Fedor F Prados Julien J Renzoni Adriana A Panasenko Olesya O OO
Nucleic acids research 20210201 4
Antibiotic resistance is a serious problem which may be caused by bacterial dormancy. It has been suggested that bacterial toxin-antitoxin systems induce dormancy. We analyzed the genome-wide role of Staphylococcus aureus endoribonuclease toxin MazF using RNA-Seq, Ribo-Seq and quantitative proteomics. We characterized changes in transcriptome, translatome and proteome caused by MazF, and proposed that MazF decreases translation directly by cleaving mRNAs, and indirectly, by decreasing translatio ...[more]