Dataset Information

Passive Microwave Radiometry for the Diagnosis of Coronavirus Disease 2019 Lung Complications in Kyrgyzstan.

ABSTRACT: The global spread of severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19), could be due to limited access to diagnostic tests and equipment. Currently, most diagnoses use the reverse transcription polymerase chain reaction (RT-PCR) and chest computed tomography (CT). However, challenges exist with CT use due to infection control, lack of CT availability in low- and middle-income countries, and low RT-PCR sensitivity. Passive microwave radiometry (MWR), a cheap, non-radioactive, and portable technology, has been used for cancer and other diseases' diagnoses. Here, we tested MWR use first time for the early diagnosis of pulmonary COVID-19 complications in a cross-sectional controlled trial in order to evaluate MWR use in hospitalized patients with COVID-19 pneumonia and healthy individuals. We measured the skin and internal temperature using 30 points identified on the body, for both lungs. Pneumonia and lung damage were diagnosed by both CT scan and doctors' diagnoses (pneumonia+/pneumonia-). COVID-19 was determined by RT-PCR (covid+/covid-). The best MWR results were obtained for the pneumonia-/covid- and pneumonia+/covid+ groups. The study suggests that MWR could be used for diagnosing pneumonia in COVID-19 patients. Since MWR is inexpensive, its use will ease the financial burden for both patients and countries. Clinical Trial Number: NCT04568525.

SUBMITTER: Osmonov B

PROVIDER: S-EPMC7914607 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Passive Microwave Radiometry for the Diagnosis of Coronavirus Disease 2019 Lung Complications in Kyrgyzstan.

Osmonov Batyr B Ovchinnikov Lev L Galazis Christopher C Emilov Berik B Karaibragimov Mustafa M Seitov Meder M Vesnin Sergey S Losev Alexander A Levshinskii Vladislav V Popov Illarion I Mustafin Chingiz C Kasymbekov Turat T Goryanin Igor I

Diagnostics (Basel, Switzerland) 20210207 2

The global spread of severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19), could be due to limited access to diagnostic tests and equipment. Currently, most diagnoses use the reverse transcription polymerase chain reaction (RT-PCR) and chest computed tomography (CT). However, challenges exist with CT use due to infection control, lack of CT availability in low- and middle-income countries, and low RT-PCR sensitivity. Passive microwave radiometry (MWR) ...[more]

PMID: 33562419

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Project description:ObjectiveMicrowave Radiometry is a non-invasive method which determines within seconds the in vivo temperature of internal tissues at a depth of 3-7 cm with an accuracy of ±0.2°C. In this proof-of-concept study, we tested the hypothesis that, in absence of relevant clinical signs, increased local temperature detected by microwave radiometry reflects subclinical synovial inflammation, using ultrasound as reference method.MethodsKnees of healthy controls, subjects with recent knee trauma and symptom-free patients with rheumatoid arthritis (RA) or osteoarthritis were examined by placing the microwave radiometry sensor, a) at the upper one third of the anterior surface of the thigh (control-point), and b) over the suprapatellar recess. Ultrasound was performed immediately after and the possible presence of fluid and/or synovitis was correlated with microwave radiometry findings.ResultsIn 30 healthy and 10 injured knees the temperature was always lower than thigh (32.3±1.1 and 31.8±1.4 versus 34.1±0.9 and 33.6±1.2°C with a difference (ΔΤ) of -1.8±0.2 and -1.9±0.4°C respectively). Of 40 RA and 20 osteoarthritis knees examined, ultrasound findings indicative of subclinical inflammation (fluid effusion and/or Doppler signal) were found in 24 and 12, respectively, in which the temperature was higher than healthy knees and ΔΤ was lower (-0.9±0.7 in RA and -1.0±0.5 in osteoarthritis versus -1.8±0.2°C, p<0.001). The 5 RA knees with power Doppler findings indicative of grade 2 inflammation had a ΔΤ 3 times lower compared to healthy (-0.6±0.6, p = 0.007), whereas the 9 RA and the 7 osteoarthritis knees with additionally fluid effusion, had even lower ΔΤ (-0.4±0.7, p<0.001).ConclusionUsing a safe, rapid and easy-to-perform method, such as microwave radiometry, thermal changes within the knee joint may reflect non-clinically apparent joint inflammation. Refinement of this method, including production of sensors for small joints, could result to the development of the ideal objective tool to detect subclinical synovitis in clinical practice.

Dataset Information

Passive Microwave Radiometry for the Diagnosis of Coronavirus Disease 2019 Lung Complications in Kyrgyzstan.

Publications

Passive Microwave Radiometry for the Diagnosis of Coronavirus Disease 2019 Lung Complications in Kyrgyzstan.

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