Ontology highlight
ABSTRACT:
SUBMITTER: Knelson EH
PROVIDER: S-EPMC7916546 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Knelson Erik H EH Patel Shetal A SA Sands Jacob M JM
Cancers 20210210 4
Despite recent advances in first-line treatment for small-cell lung cancer (SCLC), durable responses remain rare. The DNA repair enzyme poly-(ADP)-ribose polymerase (PARP) was identified as a therapeutic target in SCLC using unbiased preclinical screens and confirmed in human and mouse models. Early trials of PARP inhibitors, either alone or in combination with chemotherapy, showed promising but limited responses, suggesting that selecting patient subsets and treatment combinations will prove cr ...[more]