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Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions.

ABSTRACT: Organophosphorus compounds (OPCs) are able to interact with various biological targets in living organisms, including enzymes. The binding of OPCs to enzymes does not always lead to negative consequences for the body itself, since there are a lot of natural biocatalysts that can catalyze the chemical transformations of the OPCs via hydrolysis or oxidation/reduction and thereby provide their detoxification. Some of these enzymes, their structural differences and identity, mechanisms, and specificity of catalytic action are discussed in this work, including results of computational modeling. Phylogenetic analysis of these diverse enzymes was specially realized for this review to emphasize a great area for future development(s) and applications.

SUBMITTER: Lyagin I

PROVIDER: S-EPMC7916636 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions.

Lyagin Ilya I Efremenko Elena E

International journal of molecular sciences 20210210 4

Organophosphorus compounds (OPCs) are able to interact with various biological targets in living organisms, including enzymes. The binding of OPCs to enzymes does not always lead to negative consequences for the body itself, since there are a lot of natural biocatalysts that can catalyze the chemical transformations of the OPCs via hydrolysis or oxidation/reduction and thereby provide their detoxification. Some of these enzymes, their structural differences and identity, mechanisms, and specific ...[more]

PMID: 33578824

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