Ontology highlight
ABSTRACT:
SUBMITTER: Elsayed AM
PROVIDER: S-EPMC7918312 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Elsayed Abdelrahman M AM Bayraktar Emine E Amero Paola P Salama Salama A SA Abdelaziz Abdelaziz H AH Ismail Raed S RS Zhang Xinna X Ivan Cristina C Sood Anil K AK Lopez-Berestein Gabriel G Rodriguez-Aguayo Cristian C
International journal of molecular sciences 20210213 4
Many long noncoding RNAs have been implicated in tumorigenesis and chemoresistance; however, the underlying mechanisms are not well understood. We investigated the role of PRKAR1B-AS2 long noncoding RNA in ovarian cancer (OC) and chemoresistance and identified potential downstream molecular circuitry underlying its action. Analysis of The Cancer Genome Atlas OC dataset, in vitro experiments, proteomic analysis, and a xenograft OC mouse model were implemented. Our findings indicated that overexpr ...[more]