Ontology highlight
ABSTRACT:
SUBMITTER: Feng T
PROVIDER: S-EPMC5295437 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Feng Tingting T Zheng Lin L Liu Feng F Xu Xiaoying X Mao Sheng S Wang Xiao X Liu Juan J Lu Yi Y Zhao Weiming W Yu Xiuping X Tang Wei W
Oncotarget 20160901 36
Progranulin (PGRN) is an autocrine growth factor with tumorigenic roles in various tumors including cervical cancer. In this study, we investigated mammalian target of rapamycin (mTOR) signaling in response to PGRN induction and the contribution of the PGRN-stimulated PI3K/Akt/mTOR signaling pathway in the transformation and progression of cervical cancer. Here we identified a strong linkage between PGRN and phosphorylated-mTOR in cervical cancer tissues. PGRN promoted the phosphorylation of mTO ...[more]