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Prognostic value of miR-339-5p in patients with prostate cancer and its effects on tumor progression.

ABSTRACT: Prostate cancer places a serious health burden on males. The present study aimed to explore the potential prognostic significance and biological function of microRNA (miR)-339-5p in patients with prostate cancer. The expression of miR-339-5p was detected in prostate cancer tissues and cell lines by using reverse transcription-quantitative PCR. Kaplan-Meier survival curves and Cox regression analyses were used to investigate the prognostic significance of miR-339-5p in prostate cancer. The Cell Counting Kit-8 assay was used to determine the effect of miR-339-5p on prostate cancer cell proliferation. Transwell assays were used to assess the effect of miR-339-5p on cell migration and invasion. The results indicated that the expression of miR-339-5p was downregulated in prostate cancer tissues and cell lines. Downregulation of miR-339-5p was significantly associated with the Gleason score, lymph node metastasis and TNM stage. Patients with high miR-339-5p expression levels had a longer survival time than those with low expression levels. Multivariate Cox regression analysis indicated that miR-339-5p may be an independent prognostic factor for the overall survival of patients with prostate cancer. Overexpression of miR-339-5p inhibited the proliferation, migration and invasion of prostate cancer cells. Taken together, these results indicated that miR-339-5p functions as a suppressor gene in prostate cancer and acts by inhibiting cell proliferation, migration and invasion of prostate cancer cells. miR-339-5p may serve as an independent prognostic biomarker and therapeutic target for the treatment of prostate cancer.

SUBMITTER: Pan H

PROVIDER: S-EPMC7918444 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Prognostic value of miR-339-5p in patients with prostate cancer and its effects on tumor progression.

Pan Huafeng H Rui Xin X Wei Wei W Shao Siliang S Zhu Yudi Y

Experimental and therapeutic medicine 20210224 4

Prostate cancer places a serious health burden on males. The present study aimed to explore the potential prognostic significance and biological function of microRNA (miR)-339-5p in patients with prostate cancer. The expression of miR-339-5p was detected in prostate cancer tissues and cell lines by using reverse transcription-quantitative PCR. Kaplan-Meier survival curves and Cox regression analyses were used to investigate the prognostic significance of miR-339-5p in prostate cancer. The Cell C ...[more]

PMID: 33680112

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Dataset Information

Prognostic value of miR-339-5p in patients with prostate cancer and its effects on tumor progression.

Publications

Prognostic value of miR-339-5p in patients with prostate cancer and its effects on tumor progression.

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