Patient-Specific Network for Personalized Breast Cancer Therapy with Multi-Omics Data.
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ABSTRACT:
SUBMITTER: Cava C
PROVIDER: S-EPMC7918754 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Patient-Specific Network for Personalized Breast Cancer Therapy with Multi-Omics Data.
Cava Claudia C Sabetian Soudabeh S Castiglioni Isabella I
Entropy (Basel, Switzerland) 20210211 2
The development of new computational approaches that are able to design the correct personalized drugs is the crucial therapeutic issue in cancer research. However, tumor heterogeneity is the main obstacle to developing patient-specific single drugs or combinations of drugs that already exist in clinics. In this study, we developed a computational approach that integrates copy number alteration, gene expression, and a protein interaction network of 73 basal breast cancer samples. 2509 prognostic ...[more]
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