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Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device.

ABSTRACT: Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 ?L of extracted plasma with a high extraction yield (~45%) in 16 min.

SUBMITTER: Kim J

PROVIDER: S-EPMC7919272 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device.

Kim Jaehoon J Yoon Junghyo J Byun Jae-Yeong JY Kim Hyunho H Han Sewoon S Kim Junghyun J Lee Jeong Hoon JH Jo Han-Sang HS Chung Seok S

Sensors (Basel, Switzerland) 20210215 4

Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-intersti ...[more]

PMID: 33671983

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