Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC7919421 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Guo Yizhan Y Wang Qing Q Li Dongge D Onyema Oscar Okwudiri OO Mei Zhongcheng Z Manafi Amir A Banerjee Anirban A Mahgoub Bayan B Stoler Mark H MH Barker Thomas H TH Wilkes David S DS Gelman Andrew E AE Kreisel Daniel D Krupnick Alexander Sasha AS
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20190802 10
Despite standardized postoperative care, some lung transplant patients suffer multiple episodes of acute and chronic rejection while others avoid graft problems for reasons that are poorly understood. Using an established model of C57BL/10 to C57BL/6 minor antigen mismatched single lung transplantation, we now demonstrate that the recipient microbiota contributes to variability in the alloimmune response. Specifically, mice from the Envigo facility in Frederick, Maryland contain nearly double th ...[more]