Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC7919521 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Hu Xuqiao X Zhou Zhenru Z Li Fei F Xiao Yang Y Wang Zhaoyang Z Xu Jinfeng J Dong Fajin F Zheng Hairong H Yu Rongmin R
Heliyon 20210301 3
Contributing to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clinical treatment, a drug library encompassing approximately 3,142 clinical-stage or FDA-approved small molecules is profiled to identify the candidate therapeutic inhibitors targeting nucleocapsid protein (N) and spike protein (S) of SARS-CoV-2. 16 screened candidates with higher binding affinity are evaluated via virtual screening. Comparing to those under trial/temporarily used antivirus drugs (i.e., umifenovir, lop ...[more]